Immunotherapy

CUSTOMIZED DENDRITIC CELL IMMUNOTHERAPY IN CANCER

Denvax Delays Cancer Progression and Improves Survival

DENVAX is dendritic cell based cancer immunotherapy. Dendritic cells (DC) therapy delays
cancer progression and improves patient survival. At ICT, we have treated a number cancer
patients with M1 (metastatic) disease who are leading a recurrence-free quality life for
many months to years. We have the experience in treating more than a thousand patients
suffering from cancer in various stages of the disease.

Denvax Helps To Prevent Relapse

DENVAX shows most promise at preventing a recurrence of cancer after surgery, chemotherapy or radiation because the immune system will need to recognize and attack a smaller number of cancer cells.

Denvax Can Be Given In Combination With Other Modalities Of Cancer

DENVAX can be given alone or in combination with the other treatment modalities.
Dendritic cell therapy comes under the heading of Biological Therapy of Cancer, the fourth
modality of cancer treatment after surgery, radiation and chemotherapy.

Negligible Adverse Effects Or Toxicity As Compared To Chemotherapy

DENVAX is customized treatment. It is designed to be safe and has minimal side effects. Some patients may experience fever for a day or two after taking DENVAX therapy. The components of DENVAX include patient’s own mononuclear cells manipulated into cancerfighting dendritic cells; there is no graft versus host reaction, or acute-or delayed-type hypersensitivity.

Ease Of Denvax Manufacturing And Administration

To manufacture DENVAX, patient’s own mononuclear cells are collected either by drawing a fresh sample of peripheral blood or by apheresis procedure. The CD14+ cells are isolated and further processed for 8 days to transform them into cancer-specific DC. These dendritic cells are then re-infused into the same patient on the 8th day of drawing blood.

Cancer immunotherapy offers the possibility for long-term cancer remission

Immunotherapy can “train” the immune system to remember cancer cells. This “immunomemory” may result in longer-lasting remissions
Clinical studies on long-term overall survival have shown that the beneficial responses to cancer

Cancer immunotherapy may not cause the same side effects as chemotherapy and radiation

Cancer immunotherapy is focused on the immune system and is often more targeted than conventional cancer treatments such as chemotherapy or radiation

Both chemotherapy and radiation damage healthy cells, leading to common side effects such as hair loss and nausea/vomiting

  • These side effects may be less likely with immunotherapy

Side effects of cancer immunotherapy will vary depending on which type of immunotherapy is used

  • They are usually related to stimulation of the immune system and can range from minor symptoms of inflammation (eg, fever) to major conditions similar to autoimmune disorders

Cancer immunotherapy can work on many different types of cancer

Immunotherapy enables the immune system to recognize and target cancer cells, making it a universal answer to cancer

The list of cancers that are currently treated using immunotherapy is extensive and includes:

  • Bladder cancer
  • Colorectal cancer
  • Lung cancer
  • Brain cancer
  • Gastric cancer
  • Ovarian cancer
  • Breast cancer
  • Kidney cancer
  • Cervical cancer
  • Lymphoma/ Leukemia
  • Skin cancer (melanoma)